Wellbutrin, insomnia & depression

Insomnia occurs in 18.6% of patients who take bupropion (Wellbutrin). Two percent of patients discontinue bupropion because of insomnia and agitation. Interestingly, 19.8% of patients experience sedation instead of insomnia. Decreasing the dose, adding a sedative drug or switching to a different antidepressant may alleviate the problem.